Gliptins: A New Class of Oral Antidiabetic Agents
نویسندگان
چکیده
India has the largest population of patients with type 2 diabetes mellitus. The conventional agents used to treat type 2 diabetes frequently exhibit reduced efficacy over time leading to inadequate glycaemic control and are also associated with adverse effects. Hence, there is a need for alternative therapies that can overcome the limitations associated with conventional antidiabetic agents. This review focuses on Gliptins, which have become a research area of intense focus and present an alternative therapeutic strategy for patients with type 2 diabetes. Gliptins show significant improvements in glycaemic control and are well tolerated, particularly with regard to weight change and hypoglycemia. Hence, gliptins are considered as useful agents for the treatment of type 2 diabetes mellitus.
منابع مشابه
Comparative analysis of therapeutic efficiency and costs (experience in Bulgaria) of oral antidiabetic therapies based on glitazones and gliptins
Type 2 diabetes mellitus is a serious, chronic, progressive and widespread disease. Metformin is the most commonly prescribed initial therapy, but combination with other antidiabetic agents usually becomes necessary due to the progression of the disease. Pioglitazone is recommended as a second-line therapy because of its strong antihyperglycemic effect and its ability to reduce insulin resistan...
متن کاملPotential role of linagliptin as an oral once-daily treatment for patients with type 2 diabetes
BACKGROUND Linagliptin is an oral antihyperglycemic agent that selectively inhibits the enzyme dipeptidyl peptidase-4 (DPP-4). Inhibition of DPP-4 increases the levels of the incretin hormones glucagon-like peptide and glucose-dependent insulinotropic polypeptide by preventing their degradation. OBJECTIVE We reviewed the role of linagliptin as an oral once-daily treatment for patients with ty...
متن کاملGliptins: a new class of oral hypoglycaemic agent.
The epidemic of type 2 diabetes worldwide continues unabated. Despite a number of existing therapies, treatment goals are seldom fully achieved. While insulin resistance and beta cell failure remain important in the pathogenesis of the condition, the role of incretin hormones in glucose homeostasis has recently become clearer. Incretins have several glucoregulatory mechanisms, and a novel appro...
متن کاملAntidiabetic treatment with gliptins: focus on cardiovascular effects and outcomes
The traditional oral pharmacological therapy for type 2 diabetes mellitus (T2DM) has been based on the prescription of metformin, a biguanide, as first line antihyperglycemic agent world over. It has been demonstrated that after 3 years of treatment, approximately 50% of diabetic patients could achieve acceptable glucose levels with monotherapy; but by 9 years this had declined to only 25%. The...
متن کاملClinical Efficacy of Gliptins for Glycemic Control in Type 2 Diabeties Mellitus
The Gliptins, a new class of oral anti-diabetic drugs for type 2 diabetes mellitus, lower blood glucose by inhibiting the enzyme dipeptidyl peptidase 4 and hence increasing the circulating levels of incretins (i.e gut hormones which can boost insulin levels). This article reviews the current evidence on the effectiveness of gliptins and suggest several ways in which these drugs could be used in...
متن کامل